Protective effects of Pluchea lanceolata on dementia induced by omeprazole in experimental rats

Omeprazole is the most commonly used proton pump inhibitor (PPI), a prospective cohort study reported that chronic use of PPI’s cause dementia. The present aimed to evaluate protective effect hydro alcoholic extract Pluchea lanceolata (HAEPL) on dementia induced by omeprazole in experimental rats. Total 42 trained rats were divided into 7 groups, each group with six First received normal food and water for 21 days. Three groups animals treated 20mg/kg 7, 14 days respectively. Another three 400mg/kg HAEPL + Behavioural studies conducted 0th, 7th, 14th 21st treatment using actophotometer, elevated plus maze (EPM) cook’s pole climbing apparatus. next day behaviour respective sacrificed, brain was isolated estimation antioxidant, neurotransmitters histopathological studies. Locomotor activity, number entry open arms time taken climb poles significantly reduced 20 mg/kg whereas learning, memory restored respect duration exposure. Alteration antioxidant enzyme, neurotransmitter level events found disease control which also corrected administration HAEPL. Co-administration P, diminishes progress caused may be potential corner stone strategies researchers clinicians.